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HK2 binds to mitochondrial voltage-dependent anion channel 1 (VDAC1) to prevent the opening of the mitochondrial permeability transition pore (MPTP) [30,37] , thereby inhibiting apoptosis, while also regulating the Ras homolog enriched in brain (Rheb)–mechanistic target of rapamycin complex 1 (mTORC1) axis to promote proliferation